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Direktoratet for medisinske produkter (tidligere Statens legemiddelverk) har ansvaret for bytteordningen, og har konkretisert vilkårene for hva som regnes for tungtveiende medisinske grunner for et medisinbytte. Det foreligger heller ingen langtidsstudier, og det savnes gode undersøkelser hvor valeriana sammenliknes med effektive behandlingsform